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Enhancing Proprioceptive Input to Motoneurons Differentially Affects Expression of Neurotrophin 3 and Brain-Derived Neurotrophic Factor in Rat Hoffmann-Reflex Circuitry

The importance of neurotrophin 3 (NT-3) for motor control prompted us to ask the question whether direct electrical stimulation of low-threshold muscle afferents, strengthening the proprioceptive signaling, could increase the endogenous pool of this neurotrophin and its receptor TrkC in the Hoffmann-reflex circuitry. The effects were compared with those on brain-derived neurotrophic factor (BDNF) and its TrkB receptor. Stimulation of the tibial nerve, activating low-threshold proprioceptive ...