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PHLP2 is essential and plays a role in ciliogenesis and microtubule assembly in the ciliate Tetrahymena thermophila

Proteins in order to perform their biological functions, have to be properly folded. To sustain the conformational integrity of proteins, cells maintain an integrated network of several hundred proteins including molecular chaperones. Chaperonin CCT is one of the proteins involved in the quality control system in the cell and is primarily responsible for folding of cytoskeletal proteins – actin and tubulin. Recent studies have implicated the evolutionary conserved phosducin-like protein-2 ...