Nencki Institute Seminar

Dear All

It is my great pleasure to invite to you the next Nencki Institute Seminar on December the 16th at 3pm as usual.

We will host Dr Vicent Pelechano, a group leader at the SciLifeLab and the Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute. Dr Pelechano will give a lecture entitled: Dissecting gene expression with genomics, from transcriptional memory to co-translational mRNA decay


RNA abundance is controlled by the balance between its synthesis and decay. Although most research is geared towards transcription; RNA degradation is also key to control final mRNA abundance, modulate gene expression kinetics and thus control protein production. First, I will discuss the relevance of RNA degradation during the dynamic remodelling of gene expression associated to transcriptional memory. Transcriptional memory is the process by which a gene previously exposed to a stimulus is primed for its reactivation. I will show how, in addition to well know chromatin factors, modulation of mRNA degradation also contributes to this process.  Next, I will focus on the crosstalk between ribosome dynamics and mRNA degradation.  We have previously shown that during 5’-3’co-translational decay, the degradation machinery follows the last translating ribosome producing a genome-wide footprint of its position. I will describe how our lab is investigating this process also in prokaryotes with divergent RNA degradation strategies. Finally, I will show how the study of the metadegradome enables the investigation of fast, species-specific, post-transcriptional responses to environmental and chemical perturbations in unculturable microbial communities.

The meeting will take place online. Please use the following link:

Meeting ID: 982 2223 1110
Passcode: 795926

Best regards
Aleksandra Pękowska

Date of publication
10 December 2021
Date of event