Dear All

It is my great pleasure to invite to you the next Nencki Institute Seminar on December the 16th at 3pm as usual.

We will host Dr Vicent Pelechano, a group leader at the SciLifeLab and the Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute. Dr Pelechano will give a lecture entitled: Dissecting gene expression with genomics, from transcriptional memory to co-translational mRNA decay

Abstract

RNA abundance is controlled by the balance between its synthesis and decay. Although most research is geared towards transcription; RNA degradation is also key to control final mRNA abundance, modulate gene expression kinetics and thus control protein production. First, I will discuss the relevance of RNA degradation during the dynamic remodelling of gene expression associated to transcriptional memory. Transcriptional memory is the process by which a gene previously exposed to a stimulus is primed for its reactivation. I will show how, in addition to well know chromatin factors, modulation of mRNA degradation also contributes to this process.  Next, I will focus on the crosstalk between ribosome dynamics and mRNA degradation.  We have previously shown that during 5’-3’co-translational decay, the degradation machinery follows the last translating ribosome producing a genome-wide footprint of its position. I will describe how our lab is investigating this process also in prokaryotes with divergent RNA degradation strategies. Finally, I will show how the study of the metadegradome enables the investigation of fast, species-specific, post-transcriptional responses to environmental and chemical perturbations in unculturable microbial communities.

The meeting will take place online. Please use the following link: https://zoom.us/j/98222231110?pwd=Uyt6Q29BaGlLSXBsUnJRQnpWc0pJZz09

Meeting ID: 982 2223 1110
Passcode: 795926

Best regards
Aleksandra Pękowska