Nencki Institute Seminar

Dear All,

Our seminars will re-start in a week. Thursday, January the 14th, at 3pm, Professor Jakub Włodarczyk, head of the Laboratory of Cell Biophysics, will give a lecture entitled: „Signaling between serotonin receptors and the extracellular matrix in stress related disorders and stress resilience”



Although many individuals experience stressful events and are exposed to trauma during life, most do not develop psychiatric illnesses such as Major Depressive Disorder – these individuals are stress-resilient. Previously, we showed a causal link between serotonin 5-HT7R-mediated signaling and extracellular cleavage of the cell adhesion molecule, CD44, by matrix metalloproteinase 9 (MMP-9), which in turn engages Cdc42 to regulate synaptogenesis, LTP, and structural plasticity of dendritic spines (Bijata et al., 2017, Cell Rep.). Our recent results suggest that the resilience phenomenon is associated with the inactivation of postsynaptic 5-HT7R-mediated signaling. In support of this view, we found that activation of the 5-HT7R in the hippocampus caused depressive-like behavior, while its selective inhibition promoted stress resilience. In particular, we have shown that the activation of 5-HT7R leads to the development of depressive-like behavior in C57BL/6J mice. This phenomenon correlates with dendritic spine abnormalities in the CA1 region of the hippocampus via the activation of the 5-HT7R/MMP-9/Cdc42 signaling pathway. Concomitantly, this signaling pathway was activated in CUS animals showing depressive-like behavior while selectively knocking down the expression of the Htr7 gene in the CA1 hippocampal subregion of C57BL/6J mice promoted resilience in the same chronic stress model. Taken together, our results indicate a possible role of 5-HT7R downstream signaling proteins in aberrant synaptic plasticity, implicating the 5‑HT7R/MMP-9/Cdc42 signaling module as a possible target for the treatment of stress related disorders.

We will use zoom, here is the link:

Meeting ID: 912 6224 3656
Passcode: 485625
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13 January 2021
2021-01-14 15:00:00
2021-01-14 16:00:00