next Thursday, March 23rd, at 3pm, we will host prof. Danuta Gutowska-Owsiak, head of the Experimental and Translational Immunology Group “DGO Lab” at the Intercollegiate Faculty of Biotechnology, University of Gdańsk & Medical University of Gdańsk.
Prof. Gutowska-Owsiak is focusing on the intercellular communication and the implication of extracellular vesicles in this process. Prof. Gutowska-Owsiak will give a lecture entitled: Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of promoting allergic inflammation.
The association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier function. The mutations are also linked to additional allergic manifestations of the, so called, “allergic march”, i.e., food allergy and asthma, despite the absence of the protein in the gut and lower respiratory tract. Here we investigated the impact of filaggrin insufficiency on exosome-enriched small extracellular vesicles (sEVs) secreted by keratinocytes and their role during antigen-specific immune response. This was followed by mass spec analysis of both sEVs and cellular lipids which identified extensive remodeling on the filaggrin insufficiency background. Lastly, we proposed dysregulation of several enzymes in filaggrin knockdown keratinocytes in vitro, and in the skin of AD patients, as a plausible explanation for the observed shift in immune response.
The seminar will be followed by a get together.
With best regards