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Low-dose memantine induced working memory improvement in the allothetic place avoidance alternation task (APAAT) in young adult male rats

13.05.2014

Working memory combines newly acquired information, cognitive skill learning and executive function. Its functioning dependent on NMDA receptors, which are involved in neuronal plasticity. To assess their role simultaneously in spatial working memory and non-cognitive learning, we used NMDAR antagonists, memantine and MK-801, and the Allothetic Place Avoidance Alternation Task (APAAT). In this test rats should avoid entering a place where shocks were presented on a rotating arena which ...

Genetically encoded FRET-based biosensor for imaging MMP-9 activity

13.05.2014

In our recently published paper we have described a genetically-encoded matrix metalloproteinase-9 (MMP-9) activity biosensor. MMP-9 is an extracellular endopeptidase known to cleave a number of ...

Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin.

13.05.2014

The human genome contains approximately 20,000 protein coding genes which are responsible for the formation, development and functioning of the human body. A similar number of genes exists in the ...

The appointment of deputy directors of the Nencki Institute

12.05.2014

On the 1st May 2014 Prof. Adam Szewczyk, the director of the Institute appointed reader Hanna Fabczak and Witold Konopka as deputy directors. The candidacy of the above mentioned people ...

The Nencki Institute’s Mission

09.05.2014

On the 11th April 2014 The Scientific Council of the Nencki Institute had a meeting and at the request of the Division of Biological and Agricultural Sciences PAS, passed a resolution concerning ...