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Interaction of AnxA6 with isolated and artificial lipid microdomains; importance of lipid composition and calcium content

Niemann-Pick type C (NPC) disease is a lipid storage disorder characterized by accumulation of lipids in late endosome/lysosome (LE/LY) compartment. In our previous report we isolated membranes of the LE/LY compartment from NPC L1 skin fibroblasts with a mutation in the NPC1 gene and found that they were characterized by low fluidity which likely contributed to the impaired function of membrane proteins involved in storage and turnover of cholesterol. In this report we isolated lipid ...

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