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Tyrosine nitration affects thymidylate synthase properties

The paper demonstrates thymidylate synthase, a target enzyme in chemotherapy, to undergo tyrosine nitration in vivo, identifies potential sites of this modification and its influence on enzyme properties.


Highly purified preparations of the enzyme, isolated from normal and tumor tissues, were found to be nitrated, as indicated by a specific reaction with anti-nitro-tyrosine antibodies, suggesting this modification to appear endogenously.

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