From June 16th to 18th, 2025, the Nencki Institute of Experimental Biology hosted the 6th edition of the international conference Brain Tumors – From Biology to Therapy, a recurring event organized by prof. Bożena Kamińska-Kaczmarek. This year, the meeting was co-organized with the University of Warsaw. As always, the conference brought together a vibrant community of scientists and clinicians working in the field of neuro-oncology.

More than 100 participants attended the event, including over 20 invited speakers from Europe, Israel, the United States, and Canada. The scientific program was structured around five main sessions, featuring keynote lectures by world-renowned experts sharing the latest insights into brain tumor biology and therapeutic innovations.

The conference covered a broad range of cutting-edge topics, including: pediatric brain tumor pathobiology, glioma plasticity and tumor microenvironment, tumor immunology and immunotherapy, and emerging diagnostic and therapeutic technologies in brain tumors.

Particular highlights included sessions on single-cell and spatial multi-omics, immune-tumor interactions, CAR-T cell therapies, and innovative surgical and viral gene therapies, which sparked dynamic discussions.

A key strength of the meeting was the active involvement of early-career researchers, who had the opportunity to present their work during short oral and poster sessions. Three scientists were awarded for best poster presentations:

1. Klaudia Kiel (Mossakowski Medical Research Institute, PAS): "Reprogramming the Tumor-Immune Interface in Glioblastoma with Vaccine-Like Vesicles: Single-Cell Profiling"
2. Katarzyna Poleszak (Nencki Institute, PAS): "The short peptide interfering with osteopontin/SPP1 blocks glioma-microglia interactions and exerts antitumour effects"
3. Shriya Madan (University of Maryland, Baltimore): "Overcoming the Blood-Brain Barrier: A Boosted Osmotic Approach for Safe and Targeted Antibody Delivery in Glioblastoma"

The conference created a stimulating, collaborative atmosphere that fostered meaningful scientific exchange and new collaborations.

The conference was accompanied by networking and public awareness activities, including the HIT-GLIO Charity Run, organized as part of the HIT-GLIO project (HORIZON-MISS-2023-CANCER-01), funded by the European Union's Horizon Europe programme.

We sincerely thank all conference Sponsors, whose support was essential to the success of this event.