Dear All,

On Thursday 12.12 in the CN lecture hall we will host Dr. Mateusz C. Ambrożkiewicz. His lecture will be entitled: " Proteostatic Mechanisms of Cellular Diversification in the Developing Brain". The lecture will take place at 3 p.m. in the CN lecture hall and it will be followed by a get together.

Abstract

The formation of functional circuits in the adult brain underpins its executive role in living organisms, relying on neuronal and glial diversity, correct cellular positioning, and the establishment of dendrites and synapses. In this talk, I will present our current research on translational mechanisms and post-translational modifications driving neuronal diversification during the development of the cerebral cortex. I will focus on the post-transcriptional requirements of neuronal progenitors, highlighting the dynamics of protein synthesis and the role of ubiquitination-dependent degradation in healthy and diseased brain. I will present our findings on neurodevelopmental disorder-associated ubiquitin ligase E3C, UBE3C, in the murine cerebral cortex and human brain organoids. In my talk, I will feature the genetic replacement strategies in vivo, to study the consequences of disease-associated point mutations in UBE3C for its enzymatic activity and their functional consequences for the cortical assembly. Additionally, I will share proteomics-based approaches to identify ligase substrates and explore UBE3C-regulated signaling pathways driving cortical cell diversification. This seminar showcases the underexplored niche of ubiquitination biology in neurodevelopment, unveiling molecular insights into disease etiology and highlighting potential therapeutic strategies targeting protein ubiquitination.

Tomasz Wypych