On the next seminar of the Laboratory of Neuroinformatics Dirk Schubert (Donders Institute for Brain, Cognition and Behaviour Radboud University Nijmegen Medical Centre) will give a talk: "The Ying & Yang of neuronal network activity - Investigating E/I balance in health and disease"
"Alterations of the interplay of GABAergic inhibitory and glutamatergic excitatory signaling in neuronal networks, the so-called E/I (dys)balance, are implied to represent a mechanistic commonality in neurodevelopmental disorders. In this presentation, after defining what E/I (dys)balance conceptually reflects, we will discuss a cross-species (human-rodent) approach that allows assessing the E/I balance qualitatively and quantitatively in the neuronal circuitry. Reductionistic rodent and human iPSC derived neuronal in vitro approaches, including 2-dimensional neuronal cultures growing on multi electrode arrays, allow identifying main molecular and cellular mechanisms that contribute to altered E/I balance during early network formation and maturation. Rodent approaches, such as behavioral assessments and whole brain fluorescent imaging, allow revealing the consequences of such E/I balance alterations during the early brain development on the mature brain organization and function. For example, in Kleefstra syndrome, a genetic disorder associated with intellectual disability, we show that impaired E/I balance during early network formation may lead to very complex brain region specific changes in network organization which eventually result in prominent behavioral phenotypes."
The seminar will take place on Monday, February 6th, 11 a.m., in the CN room, with online participation possible via Zoom: https://zoom.us/j/98943929142?pwd=UkkzWDZoY1VUN3REU3lCRGk5R1daQT09 (Meeting ID: 989 4392 9142, Password: 164603).
Everybody is welcome.