Use of Ifenprodil in the treatment of chronic seizures
Patent inventors: Adam Gorlewicz, Leszek Kaczmarek

The invention relates to use of ifenprodil for the treatment of chronic or recurrent seizures that are a symptom of i.a. temporal lobe epilepsy (TLE), including, in particular, drug-resistant TLE.

Approximately 50 million people worldwide suffer from epilepsy. In approximately 40% of patients, temporal lobe epilepsy (TLE) is resistant to currently available pharmacotherapies. An important factor in the pathogenesis of the disease is the small subpopulation of the receptor for N-methyl-D-aspartate (NMDAR), which activation may play a role in initiating the development of temporal lobe epilepsy. The inventors have shown that Ifenprodil, a selective NMDAR inhibitor, inhibits chronic seizures in a mouse model of TLE. The repurposing approach may allow using ifenprodil, a marketed vasodilator, to treat TLE, including drug-resistant forms of the disease. It may also be used to prevent epileptogenesis, which may occur e.g. after brain injury.

Nencki Institute is the sole applicant.

For more information contact Technology Transfer Office.

Application number:
P.434336 (16 Jun 2020). PCT/IB2021/055317 (16 Jun 2021)
Patent status: