Dear All

it is my great pleasure to invite me to the next Nencki Institute Seminar which will take place on the 17^th of March at 3 pm as usual. Dr. Adriana Magalska, who is a member of the Laboratory of Molecular Basis of Cell Motility led by prof. Jolanta Rędowicz, will give a lecture entitled: HDAC1 drives chromatin reorganization in activated neurons

Abstract

Spatial chromatin organization is crucial for transcriptional regulation and might be particularly important in neurons since they dramatically change their transcriptome in response to external stimuli. We show that the stimulation of neurons causes condensation of large chromatin domains. This phenomenon can be observed in vitro in cultured rat hippocampal neurons as well as in vivo in the amygdala and hippocampal neurons. Activity-induced chromatin condensation is an active, rapid, energy-dependent, and reversible process. It involves calcium-dependent pathways, but is independent of active transcription. It is accompanied by the redistribution of posttranslational histone modifications and rearrangements in the spatial organization of chromosome territories. Moreover, it leads to the reorganization of nuclear speckles and active domains located in their proximity. Finally, we find that the histone deacetylase HDAC1 is the key regulator of this process. Our results suggest that HDAC1-dependent chromatin reorganization might constitute an important level of transcriptional regulation in neurons.

Please use the following link: https://zoom.us/j/98222231110?pwd=Uyt6Q29BaGlLSXBsUnJRQnpWc0pJZz09 

Meeting ID: 982 2223 1110
Passcode: 795926

Best regards,
Aleksandra Pękowska