The invention relates to the diagnosis of the pre-diabetic state and processes underlying development of diabetic state way before blood glucose levels are abnormaln and diabetes clinical symptoms occur. This may be done using the relative proportion of the level of the Wnt4 and Wnt3a proteins in blood plasma.
Briefly, in prediabetic state insulin resistant tissues (skeletal muscle and adipose tissue) produce and secrete into the blood plasma less inhibitor (Wnt4) and more activator ...
