Archives-2010

TEAM Project at the Nencki Institute

The main objective of Dr. Dobrzyn’s project is to elucidate molecular and cellular mechanisms of insulin resistance and of pancreatic beta-cell dysfunction and apoptosis, associated with obesity. Her study will be focused on the signalling pathways involved in lipid metabolism regulation, transcription factors, and functional analysis of the insulin pathway. Viral gene therapy, functional genomics and biochemical approaches will be used to uncover the molecular mechanisms of lipid-induced ...