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CD14 Mediates Binding of High Doses of LPS but Is Dispensable for TNF- Production

03.02.2014

Lipopolysaccharide is a component of Gram-negative bacteria which strongly activates macrophages inducing production of pro-inflammatory cytokines, like TNF-. This reaction is initiated by Toll-like receptor 4 (TLR4) associated with MD-2, and aims at combating bacterial infection by the immune system. An exaggerated inflammatory reaction evokes sepsis. One of mechanisms protecting an organism against sepsis is an uptake of LPS by macrophages and its intracellular detoxification. The goal ...

CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release

03.02.2014

Endocannabinoid signaling has been implicated in modulating insulin release from ß cells of the endocrine pancreas. ß Cells express CB1 cannabinoid receptors (CB1Rs), and the enzymatic machinery ...

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CD14 Mediates Binding of High Doses of LPS but Is Dispensable for TNF- Production

CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release

Stwardnienie rozsiane patogeneza i jak można pomóc

Beyond making experiments: an advice on how to become a good scientist and stay motivated in science

Neuroimaging of the human brain in LOBI – what can we measure?