Publications

Novel proteins regulated by mTOR in subependymal giant cell astrocytomas of patients with tuberous sclerosis complex and new therapeutic implications

08.09.2010

Subependymal giant cell astrocytomas (SEGAs) are rare brain tumors observed in 10-20% of patients with tuberous sclerosis complex (TSC) and are the major cause of morbidity in children and young adults with TSC. A disease is caused by mutations in one of two tumor suppressor genes TSC1 or TSC2, which result in enhancement of mTOR kinase activity, dysregulation of cell growth, abnormal differentiation and tumorigenesis. Signaling via mTOR participates in multifaceted cellular and genomic ...

Impairment of experience-dependent cortical plasticity in aged mice.

06.07.2010

Experience – dependent plasticity reorganizes connections between neurons according to importance of incoming sensory information. In mice, during the exploratory behaviour, one the most ...