Publications

Calcyclin binding protein and Siah-1 interacting protein in Alzheimer’s disease pathology: neuronal localization and possible function

15.04.2013

In this work we have studied the role of CacyBP/SIP in Alzheimer’s disease which belongs to a group of neurodegenerative diseases collectively designated as ‘‘tauopathies’’. They are characterized by the aggregation of abnormally phosphorylated tau protein which leads to formation of PHFs (paired helical filaments) or NFTs (neurofibrillary tangles) and in consequence, cause the pathology. The CacyBP/SIP protein is highly expressed in brain and its interaction with tubulin suggested ...

Interaction of AnxA6 with isolated and artificial lipid microdomains; importance of lipid composition and calcium content

15.04.2013

Niemann-Pick type C (NPC) disease is a lipid storage disorder characterized by accumulation of lipids in late endosome/lysosome (LE/LY) compartment. In our previous report we isolated membranes ...

Novel Higher-Order Epigenetic Regulation of the Bdnf Gene upon Seizures

15.04.2013

Studies in cultured non-neuronal cells have demonstrated the existence of higher-order epigenetic mechanisms, determining the relationship between expression of the gene and its position within ...

Functional anatomy of neural circuits regulating fear and extinction

28.01.2013

When an animal experiences fear in the presence of threatening stimuli, it can help it to survive in an adverse environment. However, exaggerated fear may result in anxiety disorders, which ...

Early steps of microglial activation are directly affected by neuroprotectant FK506 in both in vitro inflammation and in rat model of stroke

28.01.2013

FK506 (Tacrolimus) is a drug that is widely used after allergenic organ transplant because it blocks the activation of immune system..FK506, similarly as other immunosuppressants such as ...