In previous studies we have demonstrated that prion protein (PrP) interacts with tubulin and disrupts microtubular cytoskeleton by inducing tubulin oligomerization/aggregation. These observations may explain the molecular mechanism of toxicity of cytoplasmic PrP in transmissible spongiform encephalopathies (TSEs), the so-called prion diseases. Here, we check whether microtubule associated proteins (MAPs) that regulate microtubule stability, influence the PrP-induced oligomerization of ...
Amoeba proteus, one of the oldest eukaryotic unicellular organisms, for over a century has been widely used as a model to study cell motility. However, very little is known about molecular ...
Strong evidence suggests that memory for emotional information is much better than for neutral one. Thus, one may expect that forgetting of emotional information is difficult and requires ...
Although the sequence of the human genome has been known for ten years, still the molecular function of a considerable part of the human proteome (at least a quarter of all the human proteins) ...
MscS is a bacterial mechanosensitive channel (MS) that opens upon membrane stretch and will jettison osmolytes protecting the bacteria (together with another MS channel MscL) against lysis during ...