Publications

Endurance training-induced accumulation of muscle triglycerides is coupled to upregulation of stearoyl-CoA desaturase 1

28.02.2011

Stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids, has recently been shown to be a critical control point in regulation of liver and skeletal muscle metabolism. Herein, we demonstrate that endurance training significantly increases both SCD1 mRNA and protein levels in the soleus muscle, whereas it does not affect SCD1 expression in the EDL muscle and liver. Desaturation index (18:19/18:0 ratio), an indirect indicator of SCD1 activity, ...

5-12Hz oscillations in the barrel cortex of awake rats – Sustained attention during behavioral idling?

28.02.2011

5-12 Hz oscillations, observed in cortical local field potentials (LFP) of awake rats during quiet immobility, were proposed to be either (i) epileptic events or (ii) physiological alpha-like ...

Ceramide and ceramide 1-phosphate are negative regulator sof TNF production induced by lipopolisaccharide

29.12.2010

Upon infection, the innate immune system start to combat microorganisms. One of the main factors which activates the immune system is endotoxin – lipopolisaccharide (LPS). LPS is recognized by ...

Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice

29.12.2010

The heart of leptin-deficient ob/ob mice is characterized by pathologic left ventricular hypertrophy along with elevated triglyceride (TG) content, increased stearoyl-CoA desaturase (SCD) ...

Local injection of MK801 modifies oscillatory activity in the nucleus accumbens in awake rats

29.12.2010

Oscillatory activity of the electrical potentials recorded in the brain is believed to be essential for the proper processing of information. In recent years, high frequency oscillations (HFO ...