The Nencki Institute of Experimental Biology PAS is seeking a candidate for the position of: Postdoctoral Researcher at the Laboratory of Protein Homeostasis

Number of available positions: 1

Place of work: Laboratory of Protein Homeostasis

Researcher career profiles: R2-R3
Field of science: Biology

Type of recruitment: NCN SONATA BIS: Ubiquitin as a modulator of the mitochondrial protein import process

Requirements:

Candidate should hold a PhD in molecular biology, biochemistry, or a related field. We require independence, excellent work organization, a creative approach to research problems, team collaboration skills, and motivation. Experience in laboratory work is necessary.

Scope of the project:

Protein transport and degradation are vital mechanisms that maintain the homeostasis of the cell. The project investigates how these mechanisms integrate into the biogenesis of mitochondrial proteins. Most mitochondrial proteins are produced in the cytosol and require active transport into the organelle. Such proteins require efficient regulation and quality control before they enter mitochondria. The cytosolic ubiquitin-proteasome system plays such a regulatory role. The project's main objective is to uncover how different proteins directed to mitochondria are affected by ubiquitination. We will also identify the factors that regulate this process at the molecular level and reveal their role in physiology and pathology.

The study uses cellular and in-vitro models. You will have an opportunity to use human cell cultures, yeast Saccharomyces cerevisiae, and in-vitro protein synthesis, all combined with advanced molecular and cell biology techniques, including mass spectrometry proteomics, FACS, and confocal microscopy.

Key responsibilities of the Postdoctoral Researcher include:         

1. Designing, performing, and interpreting experiments.
2. Data presentation and preparation for publication.
3. Active participation in laboratory meetings, scientific seminars, and conferences.

Employment conditions:

Full-time employment contract within an NCN-funded project.

The position is for two years, with a possible extension.

Job starting date: December 2022 – January 2023

Application procedure and deadline:

Closing date for applications: November 28th, 2022.

Send applications to: postdoc@nencki.edu.pl . Please use "Postdoc LPH PB" as the title of your message. We will contact the selected candidates only.

We offer:

• Participation in an exciting research project
• Work in a young, international, active team in an excellent scientific environment with good access to research infrastructure
• Participation in courses and conferences

Required documents (in English):

1. Motivation letter
2. A description of your key achievements
3. CV with the list of publications
4. Contact information to at least two referees, including the direct supervisor of the applicant's PhD
5. Copy of Ph.D. diploma

You can use the foreign equivalent of a Polish academic degree if it meets at least one of the following criteria:

• is covered by the provisions of an international agreement on the equivalence of education,
• was issued by an authorized institution operating in an EU, OECD or EFTA Member State,
• was issued in another country and recognized on the basis of the regulations on the recognition of academic degrees obtained abroad (learn more about the procedure for the recognition of academic degrees: https://nawa.gov.pl/en/recognition/recognition-for-professional- purposes/recognition-of-scientific-degrees-and-titles

Contact information:

For more information, please contact: p.bragoszewski@nencki.edu.pl

Link to website: https://www.nencki.edu.pl/laboratories/laboratory-of-protein-homeostasis/

Please include the following clause in your CV:

I give consent for my personal data included in the recruitment form to be processed by Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3 (data controller) for the purposes of recruitment for postdoctoral researcher position pursuant to Regulation (EU) 2016/679 of the European Parliament and of the Council of April 27th 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC in compliance with a legal obligation to which the data controller is subject to (Art. 6 section 1 letter a) and the Act on personal data protection of May 10th 2018 (Journal of Laws of 2018, item 1000).

Information Clause

The Controller of data is Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3. Contact Details of the Personal Data Protection Officer: iod@nencki.edu.pl

Personal data in the recruitment form is collected and will be processed only for the purposes of recruitment for post-doc position conducted by Nencki Institute of Experimental Biology PAS. Giving consent for processing of your personal data is voluntary; however, it is necessary in order to take part in recruitment. I hereby state that I was informed about the right to withdraw my consent at any time. The withdrawal of the consent does not influence the lawfulness of any processing performed before the consent withdrawal.

Personal data collected in order to perform the recruitment process shall be processed throughout the period of time necessary for the organization and completion of the recruitment process, as well as for considering a possible complaint; however, not longer than up to 31.03.2023.

Personal data will not be transferred to a third party. You have the right to request the data controller for access to your personal data, to edit or limit its processing, as well as to raise an objection or transfer your data. You are also entitled to file a complaint to the supervisory body (President of the Office for Personal Data Protection).