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Genetically encoded FRET-based biosensor for imaging MMP-9 activity

13.05.2014

In our recently published paper we have described a genetically-encoded matrix metalloproteinase-9 (MMP-9) activity biosensor. MMP-9 is an extracellular endopeptidase known to cleave a number of proteins within the extracellular space and on the surface of cells. It plays a significant role in both physiological and pathological processes (such as the development of cancer). In the central nervous system it regulates the synaptic plasticity, the basis of memory and learning. MMP-9 activity ...

Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin.

13.05.2014

The human genome contains approximately 20,000 protein coding genes which are responsible for the formation, development and functioning of the human body. A similar number of genes exists in the ...

The appointment of deputy directors of the Nencki Institute

12.05.2014

On the 1st May 2014 Prof. Adam Szewczyk, the director of the Institute appointed reader Hanna Fabczak and Witold Konopka as deputy directors. The candidacy of the above mentioned people ...

The Nencki Institute’s Mission

09.05.2014

On the 11th April 2014 The Scientific Council of the Nencki Institute had a meeting and at the request of the Division of Biological and Agricultural Sciences PAS, passed a resolution concerning ...

Renovated Isotope Laboratory at the Nenckie Institute

09.05.2014