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Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia

Microglia are myeloid cells residing in the central nervous system that participate in inflammatory responses, promote injury and tissue repair. Clinical and experimental data show accumulation and tumor-driven functional polarization of microglia in glioma microenvironment that contributes to glioma pathogenesis. Using primary cultures of rat microglial cells and combining several techniques we characterized intracellular signaling pathways, global transcriptional responses and functions ...