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Raft coalescence and FcRIIA activation upon sphingomyelin clustering induced by lysenin

17.07.2012

Immunoreceptor FcRIIA of macrophages and neutrophils is involved in phagocytosis and degradation of pathogens. This receptor recognizes antibodies which coat pathogens in blood serum. After binding of antibodies, the receptor is activated and translocates in the plane of the plasma membrane. It eventually accumulates in membrane regions rich in cholesterol and sphingomyelin named rafts. At the same time, rafts merge into larger structures which accommodate cascade signaling molecules ...

Kernel Current Source Density Method

17.07.2012

The last few years have brought dramatic developments in technologies and availability of multi-channel electrodes allowing simultaneous recording of electric potential from many places in the ...

Characterization of an alcohol addiction-prone phenotype in mice

17.07.2012

According to the World Health Organization, alcohol is the third most important risk factors for the population health. Alcohol abuse leads some people to develop an incurable and fatal disease, ...

TNF- affects energy metabolism and stimulates biogenesis of mitochondria in EA.hy926 endothelial cells

17.07.2012

The vascular endothelium plays an important role in smooth muscle relaxation, vasodilation and eventually regulation of blood flow. Under various pathological conditions (e.g. hyperglycaemia) ...

Laboratory of Animal Models At the Nencki Institute

13.07.2012

Dr. Witold Konopka graduated at the Faculty of Biology and Environmental Protection at University of Silesia, and his Master Thesis was defended in the Department of Tumor Biology at Institute of ...