en

Differential effects produced by ketamine on oscillatory activity recorded in the rat hippocampus, dorsal striatum and nucleus accumbens.

31.01.2012

We have previously shown that ketamine, a drug that produces psychotic activity in humans, can enhance high-frequency oscillations (HFO) in the rat nucleus accumbens (NAc). To date, the effect of ketamine on HFO recorded in other structures is unknown. In the present study, we have used a variety of techniques, including monopolar and bipolar local field potential recordings, inverse current source density and a modeling study to examine the changes in oscillatory activity that occur in ...

The Nencki Institute of Experimental Biology, Polish Academy of Sciences, is currently seeking biologist

30.01.2012

Qualifications (main criteria): Master degree in natural sciences (biology, biotechnology) Research interest Fluency in English

Qualifications (additional criteria): The ...

Disturbance of perineuronal nets in the perilesional area after photothrombosis is not associated with neuronal death

24.01.2012

Perineuronal nets (PNNs) are a condensed form of extracellular matrix that covers the surface of a subset of neurons. Their presence limits neuronal plasticity and may protect neurons against ...

Nuclear translocation of Sgt1 depends on its phosphorylation state

24.01.2012

In this work we have studied the influence of phosphorylation of the Sgt1 protein (a Hsp90 co-chaperone) on its nuclear translocation. For that we have prepared non-phosphorylable Sgt1 mutants ...

Tyrosine nitration affects thymidylate synthase properties

23.01.2012

The paper demonstrates thymidylate synthase, a target enzyme in chemotherapy, to undergo tyrosine nitration in vivo, identifies potential sites of this modification and its influence on enzyme ...