Publications

Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage

19.09.2012

Chronic myeloid leukemia is a disorder of hematopoietic stem cells caused by the expression of BCR-ABL. Loss of p53 has not been implicated as important for the development of CML. Mutations in p53 protein are infrequent however correlate with the disease progression. The absence of p53 mutations does not exclude the possibility that other dysfunctions play an important role in CML pathology. Acetylation represents a very potent posttranslational mechanism regulating p53 stability, ...

Raft coalescence and FcRIIA activation upon sphingomyelin clustering induced by lysenin

17.07.2012

Immunoreceptor FcRIIA of macrophages and neutrophils is involved in phagocytosis and degradation of pathogens. This receptor recognizes antibodies which coat pathogens in blood serum. After ...

Kernel Current Source Density Method

17.07.2012

The last few years have brought dramatic developments in technologies and availability of multi-channel electrodes allowing simultaneous recording of electric potential from many places in the ...

Characterization of an alcohol addiction-prone phenotype in mice

17.07.2012

According to the World Health Organization, alcohol is the third most important risk factors for the population health. Alcohol abuse leads some people to develop an incurable and fatal disease, ...

TNF- affects energy metabolism and stimulates biogenesis of mitochondria in EA.hy926 endothelial cells

17.07.2012

The vascular endothelium plays an important role in smooth muscle relaxation, vasodilation and eventually regulation of blood flow. Under various pathological conditions (e.g. hyperglycaemia) ...