Publications

Silencing of ICERs (Inducible cAMP Early Repressors) results in partial protection of neurons from programmed cell death

CREB (cAMP Responsive Element Binding proteins) together with ATF (Activating Transcription Factor), CREM (cAMP Responsive Element Modulators) and ICER (Inducible cAMP Early Repressor) form a family of transcriptional regulators considered to exert multiple biological functions. In particular, CREB has been shown to play a key role in survival of various cell types, including neurons. ICERs proteins (Inducible cAMP Early Repressors) are the most effective endogenous repressors of CREB.The ...