It's my pleasure to invite you to the next Transatlantic Systems Neuroscience Seminar. It will be held on Wednesday, April 28th, 3:30 PM Polish time (9:30 AM EST).
Our guest will be Katharina Schmack (Kepecs lab, CSHL), with a talk entitled Hallucinating mice and dopamine – towards mechanistic treatment targets for psychosis.
The password is nol1917
Psychotic disorders are devastating conditions without any mechanistic treatment available.
One major hurdle in the biological study of psychosis is the challenge of rigorously probing this
condition in pre-clinical animal models. The goal of our research is to develop and exploit
innovative frameworks for the study of psychosis in mice. In our present work, where we
developed a cross-species computational psychiatry approach to probe hallucination-like
perception. This enabled us to directly relate human and mouse behavior, and to demonstrate
and dissect the causal role of striatal dopamine in hallucination-like perception. Our results
suggest a neural circuit mechanism for the long-standing dopamine hypothesis of psychosis,
and provide a new translational framework for the biological study of psychosis. This opens up
exciting possibilities for advancing the biological understanding of psychosis and to identify
mechanistic treatment targets.