Hello!

It's my pleasure to invite you to the next Transatlantic Systems Neuroscience Seminar. It will be held on  Wednesday, April 28th, 3:30 PM Polish time (9:30 AM EST).

Our guest will be Katharina Schmack (Kepecs lab, CSHL), with a talk entitled Hallucinating mice and dopamine – towards mechanistic treatment targets for psychosis.

The address is: https://us02web.zoom.us/j/194382755?pwd=NUlaQVo4b0xLVE0xNGJmSDhoenA3Zz09

The password is nol1917

Abstract:

Psychotic disorders are devastating conditions without any mechanistic treatment available.

One major hurdle in the biological study of psychosis is the challenge of rigorously probing this
condition in pre-clinical animal models. The goal of our research is to develop and exploit
innovative frameworks for the study of psychosis in mice. In our present work, where we
developed a cross-species computational psychiatry approach to probe hallucination-like
perception. This enabled us to directly relate human and mouse behavior, and to demonstrate
and dissect the causal role of striatal dopamine in hallucination-like perception. Our results
suggest a neural circuit mechanism for the long-standing dopamine hypothesis of psychosis,
and provide a new translational framework for the biological study of psychosis. This opens up
exciting possibilities for advancing the biological understanding of psychosis and to identify
mechanistic treatment targets.

Best,
TSNS Team