The Nencki Institute of Experimental Biology PAS is seeking a candidate for the position of POSTDOC.

Number of available positions: 1

Place of work: Laboratory of Cell Biophysics

Researcher career profiles: R2

Field of science: biology/biochemistry

Type of recruitment: SONATA BIS -NZ

Requirements:

• Doctoral degree in the field of biochemistry, biology or biophysics, obtained not earlier than 7 years before the year of employment in the project (not including maternity leaves).

            • Experience in laboratory work.

• Very good practical knowledge of methods in the field of molecular biology, cell culturing and imaging.

• An important criterion in the selection will also be experience in primary cell culture/ or work with animals, imaging methods (FRAP, FLIM), molecular biology methods, transfection and staining methods of neurons.

            • Scientific achievements documented by publications from the JCR list.

            • Fluent English in writing and speaking.

            • Team work skills.

• High motivation for experimental work. It is expected that during the period of employment at the Institute, Post-doc will not undertake any other work.

Scope of tasks :

The aim of our project is to check if and how S-PALM and S-NO profile changes in the brain of mice, which developed depression like symptoms. First we will induce depressive like behavior in mice by exposing them to chronic stress. After achieving behavioral effect animals will receive ketamine at different concentrations in order to achieve antidepressive effect. Finally we will perform sophisticated analysis of the structural changes of dendritic spines in brain structures associated with depression. Neurons will be stained with the lipophilic dye. We will also check the interplay between two modifications and their impact on protein localization in vitro. To investigate the functional role of each investigated molecule modification on dendritic spine morphology we will use primary hippocampal neuronal cultures transfected with plasmid encoding RFP protein. Living dendrites will be imaged before and after treatment with inhibitors using confocal microscopy.

We believe that above-mentioned PTMs, both in qualitative and quantitative manner, play critical role in the pathogenesis of depression as well as other psychiatric disorders. Results obtained by us will help in understanding the function of posttranslational modifications in the nervous system, what may bring us closer to development of more efficient antidepressive therapies.

Further information can be obtained by contacting dr. Jakub Włodarczyk, associate prof. (j.wlodarczyk@nencki.gov.pl).

We offer:

An employment contract for a period of 2 years within the frame of the SONATA BIS project; post-doc (scientific-technical) position.

Application submission procedure: 2018-10-10,

The form of submission of offers: electronically, to j.wlodarczyk@nencki.gov.pl

Required documents:

An application should include:

• CV along with a list of publications and a summary of the doctoral thesis; list of previously used research techniques;
•  letter of motivation;
• a copy of the diploma confirming PhD degree

The best-performing candidates of those meeting the criteria specified in the job advertisement will be invited to an interview with the recruitment commission. We retain the right to invite selected candidates to the interview.

 Additional information:

Personal information protection clauses to be included in application documents:

I give consent for my personal data included in the recruitment form to be processed by Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3 (data controller) for the purposes of recruitment for post-doc position pursuant to Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC in compliance with a legal obligation to which the data controller is subject to (Art. 6 section 1 letter a) and the Act on personal data protection of 10 May 2018 (Journal of Laws of 2018, item 1000).

Information Clause

The Controller of data is Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3.

Contact Details of the Personal Data Protection Officer: iod@nencki.gov.pl

Personal data in the recruitment form is collected and will be processed only for the purposes of recruitment for the post-doc position conducted by Nencki Institute of Experimental Biology PAS.

Giving consent for processing of your personal data is voluntary; however, it is necessary in order to take part in the recruitment process. I hereby state that I was informed about the right to withdraw my consent at any time. The withdrawal of the consent does not influence the lawfulness of any processing performed before the consent withdrawal.

Personal data collected in order to perform the recruitment process shall be processed throughout the period of time necessary for the organisation and completion of the recruitment process, as well as for considering a possible complaint; however, not longer than up to 31 December 2018.

Personal data will not be transferred to a third countries.

You have the right to request access to your personal from the data controller, to edit or limit its processing, as well as to raise an objection or transfer your data. You are also entitled to file a complaint to the supervisory body (President of the Office for Personal Data Protection or to the Inspector General for the Protection of Personal Data)