The publication of scientists from the Nencki Institute by: Grabowska A, Sas-Nowosielska H, Wojtas B, Holm-Kaczmarek D, Januszewicz E, Yushkevich Y, Czaban I, Trzaskoma P, Krawczyk K, Gielniewski B, Martin-Gonzalez A, Filipkowski RK, Olszynski KH, Bernas T, Szczepankiewicz AA, Sliwinska MA, Kanhema T, Bramham CR, Bokota G, Plewczynski D, Wilczynski GM, Magalska A.,published in Cell Reports, has been awarded an honorary distinction, granted by the Polish Neuroscience Society.

In the article entitled "Activation-induced chromatin reorganization in neurons depends on HDAC1 activity, the authors showed that neuronal cells respond to stimulation with condensation of large chromatin domains. This process is rapid, reversible, and energy-dependent. It is regulated by calcium-dependent signaling pathways and relies on the activity of HDAC1 histone deacetylase. It might constitute an important level of transcriptional regulation in neurons.

Read the full article here: https://www.cell.com/cell-reports/pdf/S2211-1247(22)00068-7.pdf

Grabowska et al. show that neuronal cells respond to stimulation with condensation of large chromatin domains. This process is rapid, reversible, and energy-dependent. It is regulated by calcium-dependent signaling pathways and relies on the activity of HDAC1 histone deacetylase. It might constitute an important level of transcriptional regulation in neurons.

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