The main objective of Dr. Dobrzyn’s project is to elucidate molecular and cellular mechanisms of insulin resistance and of pancreatic beta-cell dysfunction and apoptosis, associated with obesity. Her study will be focused on the signalling pathways involved in lipid metabolism regulation, transcription factors, and functional analysis of the insulin pathway. Viral gene therapy, functional genomics and biochemical approaches will be used to uncover the molecular mechanisms of lipid-induced muscle and pancreatic beta-cell dysfunctions. This will broaden the molecular understanding of obesity related diabetes and may help develop new therapeutic targets in the treatment of type 2 diabetes.

We are seeking highly motivated graduate students, PhD students and postdoctoral researchers to work on the TEAM project. Candidates from all countries are welcome to apply.
Application deadline:
September 10, 2010 (PhD and MSc students)
October 15, 2010 (post-docs)
Start date: December 1, 2010
For more details see: http://team.nencki.gov.pl/