Patent Category: Therapies

Engineered synthetic peptides, compositions containing them, and methods of their use in the treatment of malignant gliomas

The invention concerns synthetic peptides, compositions and methods of use for treating tumors infiltrated with macrophages, such as glioblastomas. Peptides target osteopontin (SPP1, OPN) protein. In orthotopic human U87-MG glioma model in nude mice, animals administered with this peptide had statistically significantly smaller tumours than mice that received the control peptide.  Peptides are water soluble, non-toxic and safe and effectively stop immunosupresive communication between the ...