A description of the invention will be available after the patent application is published. Nencki Institute is the sole applicant. For more information contact Technology Transfer Office.
A description of the invention will be available after the patent application is published. Nencki Institute is the co-applicant with University of Warsaw and National Medicines Institutes. University of Warsaw is the leader in patent protection and commercialization-related activities. For more information contact Technology Transfer Office.
A description of the invention will be available after the patent application is published. Nencki Institute is the co-applicant with University of Warsaw. University of Warsaw is the leader in patent protection and commercialization-related activities. For more information contact Technology Transfer Office.
A description of the invention will be available after the patent application is published. Nencki Institute is the sole applicant. For more information contact Technology Transfer Office.
Isolated peptides, compositions and methods of use for treating tumors infiltrated with macrophages, such as glioblastoma. For more information contact Technology Transfer Office.
A panel of blood RNA markers for the prediction of epilepsy, in particular drug resistant epilepsy, in girls aged up to 24 months with tuberous sclerosis. Nencki Institute is the co-applicant with Medical University of Warsaw, International Institute of Molecular and Cell Biology in Warsaw, and Children’s Memorial Health Institute in Warsaw. Medical University of Warsaw is the leader in patent protection and commercialization-related activities. For more…
A panel of blood RNA markers for the prediction of the occurrence of epilepsy recurrence following drug withdrawal in patients with tuberous sclerosis. Nencki Institute is the co-applicant with Medical University of Warsaw, International Institute of Molecular and Cell Biology in Warsaw, and Children’s Memorial Health Institute in Warsaw. Medical University of Warsaw is the leader in patent protection and commercialization-related activities. For more…
Description of the invention will be available after the patent application is published.
Description of the invention will be available after the patent application is published.
Description of the invention will be available after the patent application is published.
Patent was granted in Poland and Nencki Institute is the sole applicant.
The subject of the present invention is a method for detecting active, remyelinating lesions in patients diagnosed with multiple sclerosis through the determination of changes in the levels of interleukin-33 in peripheral blood and cerebrospinal fluid, which constitutes a novel marker of endogenous repair processes facilitating the monitoring of the differentiation of oligodendrocyte precursor differentiation…
The present invention relates to methods for the identification of single nucleotide polymorphisms (SNP) in the GRHL1, GRHL2 and GRHL3 genes and the use of these polymorphisms as markers to identify patients at increased susceptibility to cancer of the kidneys.
The invention relates to the diagnosis of the pre-diabetoc state and processes underlying development of diabetic state way before blood glucose levels are abnormaln and diabetes clinical symptoms occur. This may be done using the relative proportion of the level of the Wnt4 and Wnt3a proteins in blood plasma. wew ew Briefly, in prediabetic state…
A device (1) for immobilizing an animal in order to examine a selected area of the animal’s body, the device (1) comprising two upright members (2a, 2b) secured by their lower ends to a base (3), the height of the upright members (2a, 2b) being adjustable independently of one another and being adapted to be…
This invention relates generally to the field of cancer diagnostics, and in particular to the detection of an increased risk of developing a skin cancer. Specifically, the present invention relates to a method of detecting and identifying an increased risk of developing a skin cancer in a human patient based on polymorphisms of the GRHL3…
The present invention relates to a genetically encoded FRET-based biosensor to monitor the activity of matrix metalloproteinase 9 (MMP-9). MMP-9 is an extracellular acting endopeptidase implicated in both physiological and pathological processes. A genetically encoded FRET biosensor anchored in the cellular membrane allows studying the proteolytic activity of MMP-9 with high spatiotemporal resolution at the…
The present invention is related to use of marimastat or a pharmaceutically acceptable salt, solvate or polymorph thereof in preventing or treating epileptogenesis in a subject that suffered a brain insult. Said brain insult is a stroke, traumatic brain injury, or a result of status epilepticus, evoked by structural or metabolic reasons. Marimastat or a…
Oligomers of Aβ peptide are strong neurotoxins and their presence correlates with the progression of pathological changes in patients with Alzheimer’s disease (AD), especially the so-called familial form of this disease (fAD). Thus the potential therapies for this disease are considered to inhibit the formation of toxic Aβ oligomers and/or neutralize already formed Aβ oligomers.…
The present invention relates to panels of biomarker microRNAs for use in methods of diagnosing Alzheimer’s disease and related diseases and conditions in a subject. The methods involve assessing the level of said biomarker microRNA(s) in subject blood sample. The invention also relates to kits comprising said panels of biomarker microRNAs, methods of diagnosing Alzheimer’s…
A subject of the invention is a compound 3-dodecylsulfanyl-butyric acid for use as a drug, especially for use in the treatment and prevention of the development of insulin resistance. The invention also relates to a pharmaceutical composition containing 3-dodecylsulfanyl-butyric acid as an active ingredient, and to the use of 3-dodecylsulfanyl-butyric acid for the manufacture of…
A system for testing spontaneous social interactions of group-housed mice placed in an experimental apparatus comprising a plurality of compartments (101-104) bridged by corridors (105). At least one compartment (101-104) has a perforated partition wall (106,107) separating the compartment into a territory available for mice (106b, 107b) and a territory to be explored by olfaction…
A subject of the invention is a compound 8-(octadecylsulfanyl)quinoline for use as a drug, especially for use in the treatment and prevention of the development of insulin resistance. The invention also relates to a pharmaceutical composition containing 8-(octadecylsulfanyl)quinoline as an active ingredient, and to the use of 8-(octadecylsulfanyl)quinoline for the manufacture of a drug for…
Description of the invention will be available after the patent application is published. For more information contact Technology Transfer Office.
A scanning microscope system for forming an image of a sample is disclosed. The system comprises a first optical 5 system adapted to focus excitation light at the sample herewith causing at least one excitation light spot at the sample. The excitation light spot causes one or more optical excitations in the sample. The system…
The present invention relates to methods for the determination of the biological age of a human being. This method is based on the findings of a multinational study screening for biomarkers of aging in humans.
The patent application relates to the use of naringenin in an effective amount for slowing, counteracting and preventing the process offormation of albinotic spots on skin. The patent application also relates to a preparation containing naringenin in an effective amount as the active ingredient and cosmetically acceptable excipients, vehicle and additives, for use in slowing,…
Isolated peptides, compositions and methods of use for treating tumors infiltrated with macrophages, such as glioblastomas.
A subject of the invention is a novel peptide with chondrogenesis-stimulating activity, especially by stimulating the differentiation of adipose tissue mesenchymal stem cells into chondrocytes and a stimulator of adipose tissue stem cell proliferation, migration and chemotaxis. Also a subject of the invention is the medical use of the peptide as a drug for the…
Tetrahymena is used as a host cell in a biological assay for identification of modulators of tubulin ligases.
Nencki Institute is the co-applicant in this application together with University of Gdańsk who is the coordinator in this case and the primary contact.
The subject of the patent application is a pharmaceutical composition that contains an IM peptide at a concentration of 0.1 – 50 µg/ml and/or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable vehicle and/or diluent. Also the subject of the patent application is a set for stimulating regeneration of complex tissue or…
The present invention relates to chemical compounds with injury-reducing and/or neuroprotective properties. The compounds are preferably selected from the group: RGD1; RGD2; RGD3; RGD4; AcRGDl; AcRGD3, RGD10-PM; RGD10-PS. A subject of the invention is a method for the preparation of the compound RGD10-PS, and its derivatives, by biological means. Moreover, a subject of the invention…
The present invention relates to novel peptide derivatives of platelet derived growth factor (PDGF) and a method for their preparation. In addition, the invention relates to a pharmaceutical composition containing the new compounds and the use of these compounds as a treatment for skin problems that are difficult to heal and skin lesions of various…
In one aspect, the present invention provides a composition comprising zebularine, a nucleotide inhibitor of DNA methyltransferase, optionally in combination with retinoic acid, and said composition for use in promoting complex tissue regeneration and wound healing in a subject. In another aspect the present invention provides zebularine as a therapeutic agent, optionally in combination with…
A computer-implemented method for segmenting a 3D image comprising round objects, the method comprising the steps of dividing the 3D image (100) into 2D slice images (501, 502), for each slice image (501, 502), determining seed points (441, 442) within round areas of the slice image having brightness different than the background of the image…
The subject of the present invention are mutant strains of Escherichia coli MG6165 (ATCC nr 47076) lacking all potassium transporters: Kdp, Kup and Trk (?Ktrans), encompassing strains lacking at least one of the genes encoding mechanically gated channels mscS and mscL (?Ktrans ?mscS i/lub ?mscL). In particular, it concerns Escherichia coli MG61655 (ATCC No. 47076)…
Leszek Kaczmarek, Witold Konopka, Kamila Duniec P.381605 (25 Jan 2007), EP 20080705168 (23 Aug 2009) EP 2109361 (28 Dec 2011) Lapsed
Methods for delivering a biologically active molecule into a cell by linking a molecule to the cell surface, wherein the molecule can act as a surface receptor, then complexing the biologically active molecule with a ligand for the surface receptor, and finally contacting the biologically active molecule-ligand complex with the cell surface are disclosed. Delivery…